2-Deoxy-d-glucose: from diagnostics to therapeutics
نویسندگان
چکیده
منابع مشابه
Antiangiogenic Activity of 2-Deoxy-D-Glucose
BACKGROUND During tumor angiogenesis, endothelial cells (ECs) are engaged in a number of energy consuming biological processes, such as proliferation, migration, and capillary formation. Since glucose uptake and metabolism are increased to meet this energy need, the effects of the glycolytic inhibitor 2-deoxy-D-glucose (2-DG) on in vitro and in vivo angiogenesis were investigated. METHODOLOGY...
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2-Deoxy-2-fluoro-d-glucose (FDG) is glucose analog routinely used in clinical and animal radiotracer studies to trace glucose uptake but it has rarely been used in plants. Previous studies analyzed FDG translocation and distribution pattern in plants and proposed that FDG could be used as a tracer for photoassimilates in plants. Elucidating FDG metabolism in plants is a crucial aspect for estab...
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PURPOSE 2-Deoxy-D-glucose (2-DG), a glucose analog that accumulates in cells and interferes with carbohydrate metabolism by inhibiting glycolytic enzymes, has anticonvulsant actions. Recognizing that severe glucose deprivation can induce seizures, we sought to determine whether acute treatment with 2-DG can promote seizure susceptibility by assessing its effects on seizure threshold. For compar...
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AIMS In this study we explored the relationship between alcohol and carbohydrate consumption in long-term abstinent alcoholics. METHODS We employed an established laboratory paradigm which allowed us to stimulate and measure dietary intake. 2-Deoxy-d-glucose (2-DG) is a glucose analogue that causes an intracellular energy deprivation resulting in exaggerated food consumption and a compensator...
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Anatomic imaging of cancer using X-rays has proven very useful for more than a century but has clear limitations. Anatomic methods quite reliably show whether a large mass is present or absent, but not what the mass is composed of. Imaging additional phenotypic alterations of the altered genotype of cancers with positron emission tomography (PET)adds clinically valuable information for patient ...
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ژورنال
عنوان ژورنال: International Journal of Basic & Clinical Pharmacology
سال: 2021
ISSN: 2279-0780,2319-2003
DOI: 10.18203/2319-2003.ijbcp20212086